Wealthy businessman Isaacman has been voted in as the new administrator of NASA, ending an unusual selection saga where Trump put his name forward, pulled the nomination, and then put him forward again.
The billionaire, an private pilot who became the first private citizen to undertake a spacewalk, is also the first agency head in a generation to come straight from the private sector.
For a significant portion of the space community, the legacy of his tenure will be determined by one key benchmark: its ability to return humans to the Moon before the Chinese space program.
The President has emphasized a goal for the America to establish a permanent lunar base, both to facilitate resource extraction and to serve as a stepping stone for travel to Mars.
On Wednesday, the Senate cleared the nomination with a bipartisan vote.
Trump initially pulled the nomination in May, pointing to a "deep dive of previous relationships".
At the point, the president was engaged in a dispute with the SpaceX CEO, one of his largest political donors, with whom the nominee has professional ties.
The new administrator indicates he is now completely supportive of the administration's goal to harvest the moon, placing him in disagreement with Elon Musk, who has stated that lunar missions is a distraction from the primary objective of reaching Mars.
In the ongoing cosmic competition, world powers are competing to exploit the Moon.
“Now is not the time for hesitation but a time for action because if we fall behind, if we err, we may not recover, and the implications could alter the balance of power here on Earth,” Isaacman told the Senate committee recently.
The billionaire entrepreneur sees bringing in more industry players as key to accomplishing those goals, according to a recently leaked document outlining his strategy for NASA.
In his Senate hearing, he reaffirmed the strategy, which he developed when he was originally put forward, but clarified it was a evolving strategy.
His openness to competition could also lead to tension with Musk. Recently, Isaacman applauded the granting of a significant agreement to Blue Origin, which is one of the few rivals of SpaceX.
In the strategy paper, he recommended NASA should increasingly partner with universities and academic institutions, envisioning the agency as a "amplifier for science".
He pointed to the scheduled 2027 launch of the Nancy Grace Roman Space Telescope as a flagship example.
"And if we be approaching something extraordinary - like deploying the Roman Telescope - I will explore every option to see it launched, even providing personal financing if that's what it requires to produce the scientific results," he wrote.
According to estimates, his wealth is pegged at around $1.2 billion, accumulated through his financial services firm and the sale of his business that provided flight training and managed a private fleet of military jets.
The NASA administrator role will be his initial foray in public office, a contrast to the previous two appointees appointed as NASA chief.
He will replace the former transportation secretary, who has served as interim NASA chief since July.
Wildlife biologist specializing in sloth research with over a decade of field experience in Central and South America.